Wire-free Miniscope

UCLA open-source miniature 1-photon microscope for calcium imaging in freely moving animals. Supports both wired and wire-free configurations.

Wire-free Miniscope

Wire-free Miniscope (UCLA V4)

This is the UCLA Miniscope V4 — a popular open-source head-mounted miniature microscope designed for calcium imaging in freely behaving animals. It supports both traditional wired setups and wire-free configurations.

Official Links


Complete Component Set & Assembly Diagram

All core parts of the UCLA Miniscope V4 with clear labeling of every module.

UCLA Miniscope V4 Complete Component Set and Assembly Diagram


Rigid-Flex PCB Layout

Detailed view of the main rigid-flex PCB with all functional blocks labeled.

UCLA Miniscope V4 Rigid-Flex PCB Layout

Labeled modules:

  • Image Sensor
  • LED & EWL Drivers
  • MCU & BNO055 Sensor
  • Serializer & Power
  • Expansion Header
  • EWL Connection

Head-mounted on Freely Moving Animal

Example of wire-free / head-mounted use with real-time 6-DoF head tracking.

Miniscope on freely moving animal with tracking diagram


Miniature Head Size (Palm View)

Real photo showing the compact size of the UCLA-style miniscope head.

UCLA Miniscope head in hand


Key Features

  • Open-source design from UCLA
  • Excellent for calcium imaging in freely moving mice and rats
  • Supports wired and wire-free operation
  • Compact, lightweight head-mounted design
  • Well-documented assembly process and software ecosystem
  • High-quality 1-photon fluorescence imaging